Title : Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.

Pub. Date : 2001 Mar

PMID : 11224569






1 Functional Relationships(s)
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1 To test this theory, TEM-1 beta-lactamase was evolved using a hypermutator E. coli-based directed evolution technique with cefotaxime selection. Cefotaxime TEM-1 beta-lactamase Escherichia coli