Pub. Date : 2001 Feb 27
PMID : 11222476
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis. | Polyamines | transforming growth factor beta 1 | Homo sapiens |
| 2 | TGF-beta(1) markedly increased the capacity of VSMCs to generate the polyamine putrescine and L-proline from extracellular L-arginine. | Polyamines | transforming growth factor beta 1 | Homo sapiens |
| 3 | CONCLUSIONS: These results demonstrate that TGF-beta(1) stimulates polyamine and L-proline synthesis by inducing the genes that regulate the transport and metabolism of L-arginine. | Polyamines | transforming growth factor beta 1 | Homo sapiens |
| 4 | The ability of TGF-beta(1) to upregulate L-arginine transport and direct its metabolism to polyamines and L-proline may contribute to arterial remodeling at sites of vascular damage. | Polyamines | transforming growth factor beta 1 | Homo sapiens |