Title : Use of p53 transgenic mice in the development of cancer models for multiple purposes.

Pub. Date : 2000 Dec

PMID : 11195457






2 Functional Relationships(s)
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1 We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Benzo(a)pyrene transformation related protein 53, pseudogene Mus musculus
2 We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Benzo(a)pyrene transformation related protein 53, pseudogene Mus musculus