Pub. Date : 2000 Dec 31
PMID : 11190270
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity. | 3-deazaadenosine | caspase 3 | Homo sapiens |
| 2 | DZA induced a specific cleavage of poly ADP-ribose polymerase (PARP) and an activation of the cysteine protease caspase-3/CPP32 which is known to cleave PARP. | 3-deazaadenosine | caspase 3 | Homo sapiens |
| 3 | DZA induced a specific cleavage of poly ADP-ribose polymerase (PARP) and an activation of the cysteine protease caspase-3/CPP32 which is known to cleave PARP. | 3-deazaadenosine | caspase 3 | Homo sapiens |
| 4 | DZA-mediated nuclear DNA-fragmentation was completely blocked in the presence of a universal inhibitor of caspases (z-VAD-fmk) or the specific inhibitor of caspase-3 (z-DEVD-fmk) unlike of cycloheximide (CHX). | 3-deazaadenosine | caspase 3 | Homo sapiens |
| 5 | Taken together, these results demonstrate that DZA-induced apoptosis initiated through an active transport of DZA into human leukemia cells, is dependent on the caspase-3-like activity without de novo synthesis of proteins and possibly involves c-myc down-regulation. | 3-deazaadenosine | caspase 3 | Homo sapiens |
| 6 | Taken together, these results demonstrate that DZA-induced apoptosis initiated through an active transport of DZA into human leukemia cells, is dependent on the caspase-3-like activity without de novo synthesis of proteins and possibly involves c-myc down-regulation. | 3-deazaadenosine | caspase 3 | Homo sapiens |