Title : Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.

Pub. Date : 2001 Mar

PMID : 11181893






3 Functional Relationships(s)
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1 When applied externally, chlorzoxazone, 1-EBIO, and zoxazolamine activated rSK2 channel currents in cells dialyzed with a nominally Ca(2+)-free intracellular solution. Zoxazolamine potassium calcium-activated channel subfamily N member 2 Rattus norvegicus
2 Activation of rSK2 channels by chlorzoxazone, 1-EBIO, and zoxazolamine declined at higher drug concentrations. Zoxazolamine potassium calcium-activated channel subfamily N member 2 Rattus norvegicus
3 Zoxazolamine, when applied in combination with chlorzoxazone or 1-EBIO, partially inhibited the rSK2 channel current responses, suggesting a partial-agonist mode of action. Zoxazolamine potassium calcium-activated channel subfamily N member 2 Rattus norvegicus