Pub. Date : 2001 Feb
PMID : 11180504
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson"s disease. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 2 | To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson"s disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 3 | To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson"s disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 4 | To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson"s disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 5 | In conclusion, the inhibition of either COX-1/COX-2 by acetylsalicylic acid or preferentially COX-2 by meloxicam provided a clear neuroprotection against MPTP-toxicity on the striatal and nigral levels. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |