Title : Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.

Pub. Date : 2001 Feb

PMID : 11175792






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC). Iron aconitase 1 Mus musculus