Title : Oligonucleotide-directed peptide synthesis in a ribosome- and ribozyme-free system.

Pub. Date : 2001 Feb 13

PMID : 11171961






1 Functional Relationships(s)
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1 To investigate the possible evolutionary development of the peptidyl transfer reaction, we tried to obtain peptide bond formation without the ribosome or rRNA simply by using a piece of tRNA--an aminoacyl-minihelix--mixed with sequence-specific oligonucleotides that contained puromycin. Puromycin mitochondrially encoded tRNA glycine Homo sapiens