Pub. Date : 2001 Jan
PMID : 11168538
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance. | isospaglumic acid | cathelicidin antimicrobial peptide | Rattus norvegicus |
| 2 | The peptide neurotransmitter, N-acetylaspartylglutamate (NAAG), is a selective agonist at the type 3 metabotropic glutamate receptor (mGluR3) where it acts to decrease cAMP levels. | isospaglumic acid | cathelicidin antimicrobial peptide | Rattus norvegicus |
| 3 | The peptide neurotransmitter, N-acetylaspartylglutamate (NAAG), is a selective agonist at the type 3 metabotropic glutamate receptor (mGluR3) where it acts to decrease cAMP levels. | isospaglumic acid | cathelicidin antimicrobial peptide | Rattus norvegicus |
| 4 | These data support the hypothesis that the inhibition of KCl-stimulated [(3)H]-GABA release by NAAG is mediated via presynaptic mGluR3 on GABAergic cortical neurons and that this effect is obtained by decreasing cAMP with a consequent decrease in protein kinase A activity and L-type calcium channel conductance. | isospaglumic acid | cathelicidin antimicrobial peptide | Rattus norvegicus |