Title : Is there an analytical or diagnostic advantage from including trisialo transferrin into the fraction of carbohydrate-deficient transferrin? Lessons from a comparison of two commercial turbidimetric immunoassays with the carbohydrate-deficient transferrin determination by high-performance liquid chromatography.

Pub. Date : 2000 Nov

PMID : 11166010






2 Functional Relationships(s)
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1 RESULTS: Data from HPLC and isoelectric focusing indicate that the ChronAlco assay detects major parts of asialo, monosialo, and disialo transferrin as CDT while the CDT TIA yields CDT as the total of asialo, monosialo, disialo, and trisialo transferrin. 1,5,9-cyclododecatriene transferrin Homo sapiens
2 CONCLUSION: Including trisialo transferrin into the CDT fraction enlarges the analytical signal and therefore slightly improves assay precision but also results in a significant number of pathologic results in samples exhibiting physiologic levels of the classical CDT components asialo to disialo transferrin. 1,5,9-cyclododecatriene transferrin Homo sapiens