Title : Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes.

Pub. Date : 2001 Jan 12

PMID : 11162525






1 Functional Relationships(s)
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1 Treatment with a combination of HGF and EGF, in comparison with that of either HGF or EGF, induced tyrosine phosphorylation of both c-Met and EGF receptor (EGFR) independently and additively stimulated MAPK activity and cyclin D1 expression, resulting in additive stimulation of DNA synthesis. Tyrosine MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus