Pub. Date : 2001 Feb
PMID : 11160646
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bupivacaine and IQB-9302 induced a similar degree of block of HERG channels and induced a steep voltage-dependent decrease of the relative current. | Bupivacaine | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 2 | These results suggest that 1) bupivacaine and IQB-9302 block the open state of hKv1.5, Kv2.1, Kv4.3, and HERG channels; and 2) small differences at the N-substituent of these drugs do not affect the drug-induced block of Kv2.1, Kv4.3, or HERG, but specifically modify block of hKv1.5 channels. | Bupivacaine | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |
| 3 | These results suggest that 1) bupivacaine and IQB-9302 block the open state of hKv1.5, Kv2.1, Kv4.3, and HERG channels; and 2) small differences at the N-substituent of these drugs do not affect the drug-induced block of Kv2.1, Kv4.3, or HERG, but specifically modify block of hKv1.5 channels. | Bupivacaine | potassium voltage-gated channel subfamily H member 2 | Homo sapiens |