Title : Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.

Pub. Date : 2001 Jan

PMID : 11160138






3 Functional Relationships(s)
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1 Kidney weight, ODC activity, and GFR were correlated in diabetic and control rats given difluoromethylornithine (DFMO; Marion Merrell Dow, Cincinnati, Ohio, USA) to inhibit ODC. Eflornithine ornithine decarboxylase 1 Rattus norvegicus
2 Kidney weight, ODC activity, and GFR were correlated in diabetic and control rats given difluoromethylornithine (DFMO; Marion Merrell Dow, Cincinnati, Ohio, USA) to inhibit ODC. Eflornithine ornithine decarboxylase 1 Rattus norvegicus
3 ODC activity was elevated 15-fold in diabetic kidneys and normalized by DFMO, which also attenuated hyperfiltration and hypertrophy. Eflornithine ornithine decarboxylase 1 Rattus norvegicus