Title : Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.

Pub. Date : 2001 Feb

PMID : 11156944






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 However, it is not fully understood how PMA activates TACE and induces ectodomain shedding. Tetradecanoylphorbol Acetate ADAM metallopeptidase domain 17 Homo sapiens
2 Exogenous H2O2 mimicked PMA-induced enhancement of ectodomain shedding, and H2O2-induced shedding was blocked by TAPI, a TACE inhibitor. Tetradecanoylphorbol Acetate ADAM metallopeptidase domain 17 Homo sapiens