Title : Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.

Pub. Date : 2001 Mar 30

PMID : 11139588






2 Functional Relationships(s)
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1 We demonstrate that AKT protects breast cancer cells from tamoxifen-induced apoptosis. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens
2 Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens