Title : Phosphodiesterase 5 inhibitors and nitrergic transmission-from zaprinast to sildenafil.

Pub. Date : 2001 Jan 5

PMID : 11137852






1 Functional Relationships(s)
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1 To date, the most widely used phosphodiesterase 5 inhibitors, zaprinast and sildenafil, have proved vital in the elucidation of the widespread role of cyclic GMP in nitrergic transmission and, specifically in the case of sildenafil, have provided a major breakthrough in the treatment of erectile dysfunction in men. Sildenafil Citrate 5'-nucleotidase, cytosolic II Homo sapiens