Pub. Date : 2001 Jan
PMID : 11135730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | RESULTS: Propofol hydroxylation by hepatic microsomes showed more than 19-fold variability and was most closely correlated to CYP2B6 protein content (r = 0.904), and the CYP2B6 marker activities, S-mephenytoin N-demethylation (r = 0.919) and bupropion hydroxylation (r = 0.854). | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | RESULTS: Propofol hydroxylation by hepatic microsomes showed more than 19-fold variability and was most closely correlated to CYP2B6 protein content (r = 0.904), and the CYP2B6 marker activities, S-mephenytoin N-demethylation (r = 0.919) and bupropion hydroxylation (r = 0.854). | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | All of the CYPs evaluated were capable of hydroxylating propofol; however, CYP2B6 and CYP2C9 were most active. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | CONCLUSIONS: Cytochrome P-450 2B6, and to a lesser extent CYP2C9, contribute to the oxidative metabolism of propofol. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |