Pub. Date : 2000 Dec 15
PMID : 11125002
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. | Nitrous Oxide | adrenergic receptor, alpha 2b | Mus musculus |
| 2 | Having established that N(2)O-induced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal cord, we now investigated whether activation of noradrenergic nuclei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype mediates this property. | Nitrous Oxide | adrenergic receptor, alpha 2b | Mus musculus |
| 3 | Null mice for the alpha(2B) adrenoceptor subtype exhibited a reduced or absent analgesic response to N(2)O, but their sedative response to N(2)O was intact. | Nitrous Oxide | adrenergic receptor, alpha 2b | Mus musculus |