Title : Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors.

Pub. Date : 2000 Dec 15

PMID : 11125002






1 Functional Relationships(s)
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1 Having established that N(2)O-induced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal cord, we now investigated whether activation of noradrenergic nuclei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype mediates this property. Nitrous Oxide adrenergic receptor, alpha 2a Mus musculus