Title : Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway. Implications for atherogenesis.

Pub. Date : 2001 Jan

PMID : 11121811






2 Functional Relationships(s)
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1 Platelet-induced secretion of MCP-1 and monocyte-endothelium adhesion was reduced by the MAP kinase p38-specific inhibitor SB203580, but not by other kinase inhibitors including PD98059, wortmannin, or rapamycin. SB 203580 C-C motif chemokine ligand 2 Homo sapiens
2 In addition, activated platelets induced transcription of a luciferase reporter construct containing a MCP-1 promotor, an effect that could be inhibited by SB203580. SB 203580 C-C motif chemokine ligand 2 Homo sapiens