Title : Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells.

Pub. Date : 2001 Mar 9

PMID : 11114301






1 Functional Relationships(s)
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1 A mutant form of CD47 without its Ig domain that did not induce actin polymerization or localize to rafts still enhanced T cell receptor (TCR)-dependent tyrosine phosphorylation of PLCgamma and associated Ca(2+) signaling but did not augment IL-2 secretion. Tyrosine CD47 molecule Homo sapiens