Pub. Date : 2001 Mar 9
PMID : 11114300
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of phenylarsine oxide (PAO), an inhibitor of PTP, reversibly reduced K(+) current by 55% in oocytes coinjected with ROMK1 and cSrc. | oxophenylarsine | potassium inwardly rectifying channel subfamily J member 1 | Homo sapiens |
| 2 | Addition of phenylarsine oxide (PAO), an inhibitor of PTP, reversibly reduced K(+) current by 55% in oocytes coinjected with ROMK1 and cSrc. | oxophenylarsine | potassium inwardly rectifying channel subfamily J member 1 | Homo sapiens |
| 3 | Moreover, application of herbimycin A, an inhibitor of PTK, increased K(+) current by 120% and completely abolished the effect of PAO in oocytes coexpressing ROMK1 and cSrc. | oxophenylarsine | potassium inwardly rectifying channel subfamily J member 1 | Homo sapiens |
| 4 | The effects of herbimycin A and PAO were absent in oocytes expressing the ROMK1 mutant R1Y337A in which the tyrosine residue at position 337 was mutated to alanine. | oxophenylarsine | potassium inwardly rectifying channel subfamily J member 1 | Homo sapiens |
| 5 | Moreover, the effect of PAO was completely abolished by treatment of oocytes with 20% sucrose and 250 microg/ml concanavalin A, agents that inhibit the endocytosis of ROMK1 channels. | oxophenylarsine | potassium inwardly rectifying channel subfamily J member 1 | Homo sapiens |