Title : A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation.

Pub. Date : 2001 Jan 2

PMID : 11114163






1 Functional Relationships(s)
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1 Natural variants of TEM-1 with increased antibiotic resistance have appeared in response to the use of extended-spectrum beta-lactam antibiotics (e.g., ceftazidime) and beta-lactamase inhibitors (e.g., clavulanic acid). Ceftazidime CD248 molecule Homo sapiens