Pub. Date : 2001 Mar 23
PMID : 11113122
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Binding of levosimendan, a calcium sensitizer, to cardiac troponin C. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 2 | In the current work, we have studied the interaction of levosimendan with Ca(2+)-saturated cTnC by heteronuclear NMR and small angle x-ray scattering. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 3 | A specific interaction between levosimendan and the Ca(2+)-loaded regulatory domain of recombinant cTnC(C35S) was observed. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 4 | The changes in the NMR spectra of the N-domain of full-length cTnC(C35S), due to the binding of levosimendan to the primary site, were indicative of a slow conformational exchange. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 5 | Moreover, it was shown that levosimendan was in fast exchange on the NMR time scale with a secondary binding site in the C-domain of both cTnC(C35S) and cTnC(A-Cys). | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 6 | Moreover, it was shown that levosimendan was in fast exchange on the NMR time scale with a secondary binding site in the C-domain of both cTnC(C35S) and cTnC(A-Cys). | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 7 | The small angle x-ray scattering experiments confirm the binding of levosimendan to Ca(2+)-saturated cTnC but show no domain-domain closure. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |