Title : Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation.

Pub. Date : 2001 Mar 16

PMID : 11108720






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1. U 0126 ribosomal protein S6 kinase B2 Homo sapiens
2 Furthermore, S6K2 mutants with C-terminal deletion or acidic phosphorylation site mutations displayed greatly reduced U0126 sensitivity. U 0126 ribosomal protein S6 kinase B2 Homo sapiens