Title : Desensitization of beta2-adrenoceptor and hypersensitization to phosphodiesterase inhibitors elicited by beta2-agonists in guinea pig eosinophils.

Pub. Date : 2000 Nov

PMID : 11080712






2 Functional Relationships(s)
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1 RESULTS: A23187-induced EPO release from guinea pig eosinophils was inhibited in a concentration-dependent manner by pretreatment for 5 minutes with fenoterol, clenbuterol, and salbutamol. Fenoterol eosinophil peroxidase Cavia porcellus
2 The inhibitory effects of fenoterol and clenbuterol on A23187-induced EPO release were correlated with increases in the intracellular cAMP levels evoked by either compound. Fenoterol eosinophil peroxidase Cavia porcellus