Pub. Date : 2000 Dec
PMID : 11078708
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells. | Xanthine | CF transmembrane conductance regulator | Homo sapiens |
| 2 | We performed iodide efflux, whole cell patch-clamp, and short-circuit recordings to demonstrate that the novel synthesized xanthine derivative 3, 7-dimethyl-1-isobutylxanthine (X-33) is an activator of the CFTR channel in Calu-3 cells. | Xanthine | CF transmembrane conductance regulator | Homo sapiens |
| 3 | Our results show that manipulating the chemical structure of xanthine derivatives offers an opportunity to identify further specific activators of CFTR in airway cells. | Xanthine | CF transmembrane conductance regulator | Homo sapiens |