Title : Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process.

Pub. Date : 2000 Oct

PMID : 11069660






3 Functional Relationships(s)
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1 In Saccharomyces cerevisiae, glucose activation of cAMP synthesis requires both the presence of the G-protein-coupled receptor (GPCR) system, Gpr1-Gpa2, and uptake and phosphorylation of the sugar. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C
2 Therefore, the low cAMP increases observed with fructose and low glucose in wild-type cells result only from the low sensitivity of the Gpr1-Gpa2 system and not from the intracellular sugar kinase-dependent process. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C
3 In conclusion, we have shown that the two essential requirements for glucose-induced activation of cAMP synthesis can be fulfilled separately: an extracellular glucose detection process dependent on Gpr1 and an intracellular sugar-sensing process requiring the hexose kinases. Cyclic AMP Gpr1p Saccharomyces cerevisiae S288C