Pub. Date : 2000 Nov 3
PMID : 11068030
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells. | Histamine | prepronociceptin | Rattus norvegicus |
| 2 | In rat peritoneal mast-cell preparation, nociceptin (10(-8)-10(-4) M) dose-dependently stimulated histamine release. | Histamine | prepronociceptin | Rattus norvegicus |
| 3 | Taken together, these data suggest that nociceptin, likely acting via the ORL1 receptor at the site of inflammation, might be critical for the enhancement of the inflammatory response by stimulating histamine release from mast cells. | Histamine | prepronociceptin | Rattus norvegicus |