Pub. Date : 2000 Sep-Oct
PMID : 11064274
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this investigation, we used alpha-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ODC activity and polyamine synthesis to test the hypothesis that polyamines contribute to myocardial injury in rat. | Eflornithine | ornithine decarboxylase 1 | Rattus norvegicus |
| 2 | In this investigation, we used alpha-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ODC activity and polyamine synthesis to test the hypothesis that polyamines contribute to myocardial injury in rat. | Eflornithine | ornithine decarboxylase 1 | Rattus norvegicus |
| 3 | DFMO treatment inhibited ISO-induced increases in (i) ODC activity and putrescine and spermidine levels in heart, (ii) CPK and LDH activity in plasma, and (iii) the area of subendocardial lesions. | Eflornithine | ornithine decarboxylase 1 | Rattus norvegicus |