Pub. Date : 2000 Nov
PMID : 11046142
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. | Lysine | tumor protein p53 | Homo sapiens |
| 2 | Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination. | Lysine | tumor protein p53 | Homo sapiens |
| 3 | Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination. | Lysine | tumor protein p53 | Homo sapiens |
| 4 | Those differences are also manifest in HeLa cells which express the human papillomavirus E6 protein, suggesting that p53 C-terminal lysine residues are also implicated in E6-AP-mediated ubiquitination. | Lysine | tumor protein p53 | Homo sapiens |
| 5 | These data suggest that p53 C-terminal lysine residues are the main sites of ubiquitin ligation, which target p53 for proteasome-mediated degradation. | Lysine | tumor protein p53 | Homo sapiens |
| 6 | These data suggest that p53 C-terminal lysine residues are the main sites of ubiquitin ligation, which target p53 for proteasome-mediated degradation. | Lysine | tumor protein p53 | Homo sapiens |