Title : Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4.

Pub. Date : 2000 Nov

PMID : 11038165






1 Functional Relationships(s)
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1 Of 10 cDNA-expressed human P450 enzymes examined, CYP2C19, CYP2C9, and CYP3A4 catalyzed 3",4"-diHPPH formation from the primary hydroxylated metabolites (3"-hydroxy-DPH and 4"-HPPH). hydroxyphenytoin cytochrome P450 family 2 subfamily B member 6 Homo sapiens