Pub. Date : 2000 Oct 10
PMID : 11023926
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. | Superoxides | cytochrome b-245 alpha chain | Homo sapiens |
| 2 | NAD(P)H oxidase is an important source of superoxide in human blood vessels, and some studies suggest a possible association between polymorphisms in the NAD(P)H oxidase CYBA gene and atherosclerosis; however, no functional data address this hypothesis. | Superoxides | cytochrome b-245 alpha chain | Homo sapiens |
| 3 | We examined the relationships between the CYBA C242T polymorphism and direct measurements of superoxide production in human blood vessels. | Superoxides | cytochrome b-245 alpha chain | Homo sapiens |
| 4 | CONCLUSIONS: Association of the CYBA 242T allele with reduced NAD(P)H oxidase activity in human blood vessels suggests that genetic variation in NAD(P)H oxidase components may play a significant role in modulating superoxide production in human atherosclerosis. | Superoxides | cytochrome b-245 alpha chain | Homo sapiens |