Title : Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

Pub. Date : 2000 Oct

PMID : 11018758






1 Functional Relationships(s)
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1 The level of insulin-stimulated tyrosine phosphorylation of p85alpha from phosphatidylinositol 3 (PI 3)-kinase, which is upstream of Akt, was also reduced in muscle and adipose tissue from db/db mice (P<0.05); however, there was no change in extracellular signal-regulated kinase-1 or -2 phosphorylation. Tyrosine thymoma viral proto-oncogene 1 Mus musculus