Pub. Date : 2000 Oct 10
PMID : 11016955
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. | Calcium | LDL receptor related protein 1 | Homo sapiens |
| 2 | We report that the LRP ligand, activated alpha(2)-macroglobulin (alpha(2)M*), induces robust calcium influx in cultured primary neurons, but not in nonneuronal LRP-containing cells in the same culture. | Calcium | LDL receptor related protein 1 | Homo sapiens |
| 3 | Calcium influx to alpha(2)M* is blocked by the physiological LRP inhibitor, receptor-associated protein. | Calcium | LDL receptor related protein 1 | Homo sapiens |
| 4 | Bivalent antibodies to the extracellular domain of LRP, but not Fab fragments of the same antibody, cause calcium influx, indicating that the response is specific to LRP and may require dimerization of the receptor. | Calcium | LDL receptor related protein 1 | Homo sapiens |