Title : The subcellular location of nucleoside analog phosphorylation is a determinant of synergistic effects of hydroxyurea.

Pub. Date : 2000 Sep 16

PMID : 11006103






1 Functional Relationships(s)
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1 Hydroxyurea showed synergistic cytotoxicity with the nucleoside analogs 1-beta-d-arabinofuranosylcytosine and 2-chloro-2"-deoxyadenosine when dCK was expressed in the cytosol or in the nucleus, but not when dCK was expressed in the mitochondria. Nucleosides Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster