Title : Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.

Pub. Date : 2000 Oct

PMID : 10999944






1 Functional Relationships(s)
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1 In humans, 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme CYP2A6, which can also activate tobacco smoke procarcinogens (e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone). 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone cytochrome P450 family 2 subfamily A member 6 Homo sapiens