Title : Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells.

Pub. Date : 2000 Dec 1

PMID : 10982813






2 Functional Relationships(s)
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1 The Ndi1 enzyme of Saccharomyces cerevisiae is a single subunit rotenone-insensitive NADH-quinone oxidoreductase that is located on the matrix side of the inner mitochondrial membrane. Rotenone NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C
2 Furthermore, when cells were cultured under the conditions where energy has to be provided by respiration, the NDI1-transduced cells were able to grow even in the presence of added complex I inhibitor such as rotenone and 1-methyl-4-phenylpyridinium ion. Rotenone NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C