Pub. Date : 2000 Dec 8
PMID : 10978316
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetylation of polyamines by spermidine/spermine N(1)-acetyltransferase (SSAT) has been implicated in their degradation and/or export out of the cell. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 2 | Acetylation of polyamines by spermidine/spermine N(1)-acetyltransferase (SSAT) has been implicated in their degradation and/or export out of the cell. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 3 | The relationship of SSAT to polyamine pool dynamics and cell growth is not yet clearly understood. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 4 | Growth inhibition could not be prevented with exogenous polyamines due to a previously unrecognized ability of SSAT to rapidly acetylate influxing polyamines and thereby prevent restoration of the endogenous pools. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 5 | Growth inhibition could not be prevented with exogenous polyamines due to a previously unrecognized ability of SSAT to rapidly acetylate influxing polyamines and thereby prevent restoration of the endogenous pools. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 6 | Overall, the findings demonstrate that conditional overexpression of SSAT lowers polyamine pools, inhibits cell growth, and markedly enhances growth sensitivity to certain analogs. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |