Pub. Date : 2000 Oct 1
PMID : 10974203
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The alcohol aversion therapy drug disulfiram has been shown to inhibit hepatic aldehyde dehydrogenase (ALDH), one of the key enzymes involved in ethanol metabolism. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 2 | The alcohol aversion therapy drug disulfiram has been shown to inhibit hepatic aldehyde dehydrogenase (ALDH), one of the key enzymes involved in ethanol metabolism. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 3 | We report here that when disulfiram inhibited recombinant rat liver mitochondrial ALDH (rlmALDH) in vitro, no significant molecular mass increase was detected during the first 30 min as determined by on-line HPLC-electrospray ionization mass spectrometry (LC-MS). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 4 | In addition, the peptide of M(r) = 4821 observed in the Glu-C digestion of the disulfiram-treated ALDH reverted to M(r) = 4823 after treatment with DTT, which indicated that the disulfide bond was reduced. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |