Pub. Date : 2000 Oct 27
PMID : 10969064
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. | Guanosine Diphosphate | G protein signaling modulator 1 | Homo sapiens |
| 2 | The GPR consensus peptide effectively prevented the binding of AGS3 to Gialpha1,2 in protein interaction assays, inhibited guanosine 5"-O-(3-thiotriphosphate) binding to Gialpha, and stabilized the GDP-bound conformation of Gialpha. | Guanosine Diphosphate | G protein signaling modulator 1 | Homo sapiens |
| 3 | The GPR consensus peptide also blocked receptor coupling to Gialphabetagamma indicating that although the AGS3-GPR peptide stabilized the GDP-bound conformation of Gialpha, this conformation of Gialpha(GDP) was not recognized by a G-protein coupled receptor. | Guanosine Diphosphate | G protein signaling modulator 1 | Homo sapiens |
| 4 | The GPR consensus peptide also blocked receptor coupling to Gialphabetagamma indicating that although the AGS3-GPR peptide stabilized the GDP-bound conformation of Gialpha, this conformation of Gialpha(GDP) was not recognized by a G-protein coupled receptor. | Guanosine Diphosphate | G protein signaling modulator 1 | Homo sapiens |