Title : Neurotrophins require distinct extracellular signals to promote the survival of CNS neurons in vitro.

Pub. Date : 2000 Sep

PMID : 10964491






3 Functional Relationships(s)
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1 Irrespective of the cultivation time, survival promoting effects of both BDNF and NT-3 on dopaminergic neurons were induced or potentiated upon simultaneous depolarization of cultured mesencephalic cells with NMDA or upon activation of cAMP/PKA-dependent signaling pathways with dibutyryl cAMP. Cyclic AMP 3'-nucleotidase Homo sapiens
2 Irrespective of the cultivation time, survival promoting effects of both BDNF and NT-3 on dopaminergic neurons were induced or potentiated upon simultaneous depolarization of cultured mesencephalic cells with NMDA or upon activation of cAMP/PKA-dependent signaling pathways with dibutyryl cAMP. Cyclic AMP 3'-nucleotidase Homo sapiens
3 Dibutyryl cAMP (dbcAMP), but not NMDA, also potentiated or induced the survival promoting effects of BDNF and NT-3 on cultured cerebellar granule cells. Cyclic AMP 3'-nucleotidase Homo sapiens