Title : Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes.

Pub. Date : 1999 Nov

PMID : 10964007






2 Functional Relationships(s)
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1 Mechanism-based inactivation of selected cytochrome P450 (CYP) isozymes by xenobiotics can lead to N-alkylation of the heme moiety and the formation of ferrochelatase-inhibitory N-alkylprotoporphyrin IX (N-alkylPP), resulting in hepatic porphyrin accumulation and porphyria. Porphyrins cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 Mechanism-based inactivation of selected cytochrome P450 (CYP) isozymes by xenobiotics can lead to N-alkylation of the heme moiety and the formation of ferrochelatase-inhibitory N-alkylprotoporphyrin IX (N-alkylPP), resulting in hepatic porphyrin accumulation and porphyria. Porphyrins cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus