Pub. Date : 2000 Sep
PMID : 10950803
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thalidomide treatment was found to cause potent and selective inhibition of IL-8 production in a dose-responsive manner. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | In addition, thalidomide treatment of lipopolysaccharide-stimulated microglia inhibited the activation of protein NF-kappaB, a transcription factor known to be important for IL-8 production. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | These results suggest thalidomide could have a therapeutic role in acute bacterial meningitis through inhibition of IL-8-mediated neutrophil chemotaxis. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |