Title : Inducible nitric oxide synthase knockout mouse macrophages disclose prooxidant effect of interferon-gamma on low-density lipoprotein oxidation.

Pub. Date : 2000 Aug

PMID : 10944420






3 Functional Relationships(s)
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1 TBARS formation from LDL was suppressed in IFN-gamma- and IFN-gamma/LPS-treated iNOS(+/+) macrophages but was increased in IFN-gamma-treated iNOS(-/-) macrophages. Thiobarbituric Acid Reactive Substances nitric oxide synthase 2, inducible Mus musculus
2 TBARS formation from LDL was suppressed in IFN-gamma- and IFN-gamma/LPS-treated iNOS(+/+) macrophages but was increased in IFN-gamma-treated iNOS(-/-) macrophages. Thiobarbituric Acid Reactive Substances nitric oxide synthase 2, inducible Mus musculus
3 In the presence of N(G)-monomethyl-l-arginine (l-NMMA), a NOS inhibitor, the suppressive effect of IFN-gamma and IFN-gamma/LPS was abolished and TBARS formation was even increased to a level above that of untreated iNOS(+/+) macrophage. Thiobarbituric Acid Reactive Substances nitric oxide synthase 2, inducible Mus musculus