Title : Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells.

Pub. Date : 2000 Aug

PMID : 10935541






3 Functional Relationships(s)
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1 Similarly, antiandrogenic ligands, cyproterone acetate and casodex, were also capable of translocating the cytoplasmic AR into the nucleus albeit at a slower rate than the androgen 5alpha-dihydrotestosterone (DHT). Dihydrotestosterone androgen receptor Rattus norvegicus
2 Subsequent exposure of the casodex-treated cell to DHT rapidly (15-30 min) altered the homogeneous to punctate distribution of the already translocated nuclear AR. Dihydrotestosterone androgen receptor Rattus norvegicus
3 When transported into the nucleus either by casodex or by DHT, GFP-AR was resistant to 2 M NaCl extraction, indicating that the homogeneously distributed AR is also associated with the nuclear matrix. Dihydrotestosterone androgen receptor Rattus norvegicus