Title : FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells.

Pub. Date : 2000 Aug

PMID : 10928971






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FK506 inhibited anti-CD3/CD28 induced TNF-alpha and IL-1beta production at concentrations less than 1 ng ml(-1). Tacrolimus CD28 molecule Homo sapiens
2 FK506 and CsA, but not DEX, specifically inhibited anti-CD3/CD28 induced inflammatory cytokine production without affecting the lipopolysaccaride (LPS) induced effect. Tacrolimus CD28 molecule Homo sapiens