Title : Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model.

Pub. Date : 2000 Jul

PMID : 10917206






1 Functional Relationships(s)
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1 The effect of the antithyroid drug methimazole (MMI) on cytochrome P450/P450 reductase-dependent activation of the anti-cancer prodrug cyclophosphamide (CPA) was investigated in a rat model of P450 prodrug activation-based cancer gene therapy. Methimazole cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus