Pub. Date : 2000 Aug
PMID : 10916087
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specifically, our studies assessed the possibility that oxalate-induced changes in IEG expression are mediated by phospholipase A2 (PLA2), a common pathway in cellular stress responses. | Oxalates | phospholipase A2 group IB | Canis lupus familiaris |
| 2 | Specifically, our studies assessed the possibility that oxalate-induced changes in IEG expression are mediated by phospholipase A2 (PLA2), a common pathway in cellular stress responses. | Oxalates | phospholipase A2 group IB | Canis lupus familiaris |
| 3 | In contrast, AA (25 micromol/L) attenuated the oxalate-induced increase in c-jun and egr-1 mRNA, presumably by inhibiting PLA2 activity. | Oxalates | phospholipase A2 group IB | Canis lupus familiaris |
| 4 | CONCLUSIONS: These findings suggest that PLA2 plays a major role in oxalate-induced IEG expression in renal epithelial cells and that lysophospholipids might be a possible lipid mediator in this pathway. | Oxalates | phospholipase A2 group IB | Canis lupus familiaris |