Pub. Date : 1999
PMID : 10905564
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxazaphosphorines are inactive anticancer prodrugs that are bioactivated by hepatic cytochrome P450. | oxazaphosphorines | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Besides hepatic metabolism, there is increasing interest in the possibility of intratumoral activation of oxazaphosphorines by P450. | oxazaphosphorines | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In summary, we have demonstrated that tumors of the CNS express P450, indicating that activation of prodrugs like oxazaphosphorines may take place intratumorally. | oxazaphosphorines | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |